The Webcomics Examiner has named its best webcomics of 2005 in a special feature in the new issue, a massive selection of titles that seems sort of a bulky for a best-of listing but rewards the newbie webcomics reader with tons of links to visit.

A Lesson is Learned, but the Damage is Irreversible, Dale Beran and David Hellman
A Softer World, Emily Horne and Joey Comeau
Achewood, Chris Onstad
American Elf, James Kochalka
Bee: Motel Art Improvement Service, Jason Little
Copper, Kazu Kibuishi
Dicebox, Jenn Manley Lee, Girlamatic
Digger, Ursula Vernon, Graphic Smash
Dinosaur Comics, Ryan North
Flick, Mikael Oskarsson, Graphic Smash
Girl Genius, Phil and Kaja Foglio
Hotel Fred, Roger Langridge, Modern Tales
Jellaby, Kean Soo
Little Dee, Chris Baldwin
Cat and Girl, Dorothy Gambrell, Modern Tales
The New Adventures of Death, Dorothy Gambrell
Nine Planets Without Intelligent Life, Adam Reed
The Perry Bible Fellowship, Nicholas Gurewitch
Salamander Dreams, Hope Larson
Schlock Mercenary, Howard Tayler
Smile, Raina Telgemeier
Something Positive, R.K. Milholland
The Stiff, Jason Thompson, Girlamatic
Templar, Arizona, Spike
Whispered Apologies, Various

Rather than link them up here and remove any obligation to visit the original site, I encourage you to read their write-ups and go to the various comics from their attractive link page. There is a lot of very broadly appealing work on this list. Don't forget the regular array of features, either.